API Methotrexate 59-05-2 price
Basic Info
Model No.: 59-05-2
Product Description
English name: Methotrexate
English synonym: Methotrexate Injection/Oral Grade; (S)-2-(4-((2,4-DiaMinopteridin-6-yl)Methyl)(Methyl)aMino)benzaMido)pentanedioic acid;Methotrexate;
CAS No.: 59-05-2
Molecular formula: C20H22N8O5
Molecular weight: 454.44
EINECS number: 200-413-8
Related Categories: Pharmaceutical Raw Materials; Medicines Antineoplastic Agents; Plant Hormones and Nucleic Acids; Amino Acids and Derivatives; Research Reagents;
Mol file: 59-05-2.mol
Chemical properties
Orange-yellow crystalline powder. Melting point 185-204 ° C. It is soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform and ether.
Use
1. This product is a good anti-tumor drug for acute lymphatic leukemia, lymphoma, malignant mole, choriocarcinoma, squamous cell carcinoma, lung cancer, cervical cancer, breast cancer and osteosarcoma. After oral administration of methotrexate for 12 hours, 90% of the original drug was excreted from the urine. The main metabolite was 7-hydroxy methotrexate. The intravenous LD50 of the rats was 14 mg/kg.
2. Antineoplastic agents for various acute leukemias, chorionic epithelial cell carcinoma, malignant moles and psoriasis
3. Folic acid antagonist, dihydrofolate reductase inhibitor.
The production method is obtained by condensing 2,4,5,6-tetraaminopyrimidine with dibromopropanal and then condensing with p-methylaminobenzoylglutamic acid.
Company profile Jinan Huijinchuan Chemical Co., Ltd. specializes in the supply of chemical raw materials, the main categories are Water Treatment Agent , Food Additive (Preservatives, antioxidants, color protectants) , Feed Additive , Daily Cosmetics Raw Materials the four kinds . Besides We are also agents of some Fertilizer Raw Material and Other Chemical such as organic fertilizer ， Pesticide Raw Materials , Organic Solvent , Inorganic Salt ....
Product Categories : Intermediates